RecruitingPhase 2NCT06877299

Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer

Low-Dose Radiation + Stereotactic Body Radiotherapy Followed by Tislelizumab Plus Platinum-based Chemotherapy As Neoadjuvant Therapy in Patients With Resectable StageⅡA-ⅢB Non-small Cell Lung Cancer


Sponsor

Sichuan University

Enrollment

30 participants

Start Date

Jul 4, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II study aims to evaluate the efficacy and safety of low-dose radiation + SBRT + Tislelizumab plus platinum-based chemotherapy as neoadjuvant therapy for stage II-III non-small cell lung cancer.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of low-dose whole-lung radiation, targeted high-dose radiation (SBRT), an immunotherapy drug (tislelizumab), and platinum-based chemotherapy given before surgery for stage IIA-IIIB non-small cell lung cancer that may be removable by surgery. **You may be eligible if...** - You are between 18 and 75 years old - You have untreated stage IIA-IIIB non-small cell lung cancer confirmed by biopsy or cell testing - Your tumor has been assessed by a surgical team as potentially removable - You have at least one measurable tumor on imaging - You can provide tumor tissue for PD-L1 testing **You may NOT be eligible if...** - You have already received treatment for this lung cancer - You have autoimmune disease or are on immune-suppressing medications - You have severe heart, lung, or other organ problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLow-Dose Radiation(LDRT) + Stereotactic body radiotherapy (SBRT)

Low-Dose Radiation(LDRT) + Stereotactic body radiotherapy (SBRT)


Locations(1)

West China Hospital of Sichuan University

Chengdu, China, China

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NCT06877299


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