RecruitingNot ApplicableNCT06877312

Longitudinal Study to Investigate Different Transcranial Electrical Stimulation

Longitudinal Study to Investigate Different Treatment Protocols of Transcranial Electrical Stimulation for Individuals With Dementia

Sponsor

University of Manitoba

Enrollment

200 participants

Start Date

Oct 9, 2024

Study Type

INTERVENTIONAL

Conditions

Dementia; Degenerative, Dementia Mixed

Summary

This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of 4 weeks, everyday (Monday to Friday). The study design is a longitudinal study design in which participants receive different tES randomly ordered. Treatments occur for 4 weeks, then 12 weeks of no treatment (wash-out period), repeated for each tES treatment type. Participants have the option of having their choice of music in the background while they perform cognitive exercises.

Eligibility

Min Age: 50 YearsMax Age: 95 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how different types of brain stimulation delivered through the skull (transcranial electrical stimulation) affect thinking and memory over time in people with mild cognitive impairment or early dementia. **You may be eligible if...** - You can read, write, and speak English fluently - You scored between 5 and 24 on the Montreal Cognitive Assessment (MoCA), which suggests mild to significant cognitive impairment **You may NOT be eligible if...** - You have been diagnosed with Parkinson's disease, Huntington's disease, significant speech or language problems, major depression, bipolar disorder, schizophrenia, or another major mood disorder - You have a history of epilepsy or seizures - You have vision or hearing problems severe enough to affect test performance - You have a current substance abuse disorder - You are currently in another study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial Direct Current Stimulation (tDCS)

A light electrical current with zero frequency (tDCS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through the "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

DEVICE30 Hz Transcranial Alternating Current Stimulation (tACS)

A light electrical current with 30 Hz frequency (tACS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through the "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

DEVICE50 Hz Transcranial Alternating Current Stimulation (tACS)

A light electrical current with 50 Hz frequency (tACS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through the "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

DEVICE70 Hz Transcranial Alternating Current Stimulation (tACS)

A light electrical current with 70 Hz frequency (tACS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through the "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

DEVICE90 Hz Transcranial Alternating Current Stimulation (tACS)

A light electrical current with 90 Hz frequency (tACS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through the "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

DEVICETranscranial Random Noise Stimulation (tRNS)

A light electrical current with random noise waveform (tRNS) will be applied to the scalp of the participants via 2 electrodes, while the participants perform cognitive exercises with the guidance of a trained research assistant. They have the option of having their choice of music playing in the background while they perform the cognitive exercises. Cognitive exercises: Participants will perform memory and learning games/tasks through "Mind Triggers" app on an IPad and other cognitive games. Participants will be guided by a highly trained research assistant.

Locations(1)

Riverview Health Centre

Winnipeg, Manitoba, Canada

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NCT06877312