Weight Loss Management in Endometrial Cancer Survivors

This study is testing a structured weight loss program for survivors of early-stage endometrial cancer (uterine cancer) who are overweight, to see if losing weight improves outcomes and reduces cancer recurrence risk. **You may be eligible if...** - You are 18 or older - You have a BMI of 30 or higher (clinically obese) - You have been diagnosed with stage 1 endometrioid endometrial cancer (a specific type of uterine cancer) with a normal p53 gene - You have completed surgical staging with no remaining evidence of disease - You are on active surveillance, with or without brachytherapy (a type of internal radiation) - Your general health is good to moderate (ECOG 0-2) **You may NOT be eligible if...** - You are unable to participate in a behavioral weight loss program - You have had a stroke, heart attack, end-stage liver disease, or end-stage kidney disease in the past 6 months - You are already taking a GLP-1 agonist (such as semaglutide/Ozempic) or insulin Talk to your doctor to see if this trial is right for you.