Post-operative Radiotherapy After Neodjuvant Chemo-immunotherapy and Surgery in Stage III NSCLC

This study looks at whether radiation therapy after surgery improves outcomes for people with stage III non-small cell lung cancer (NSCLC) who first received chemotherapy plus immunotherapy before surgery. The goal is to find out if post-operative radiation can lower the chance of the cancer coming back. **You may be eligible if:** - You are 18 or older with a confirmed diagnosis of non-small cell lung cancer - You have stage III disease - Your tumor does not have certain gene changes (EGFR, ALK, or ROS mutations) - You received chemotherapy combined with immunotherapy before surgery - You had surgery to remove the lung tumor - You are in good enough health to receive radiation (ECOG performance status 0–2) **You may NOT be eligible if:** - Your tumor has driver mutations like EGFR or ALK - You did not receive pre-surgery chemotherapy and immunotherapy - You are pregnant or breastfeeding - You have serious heart, lung, or immune conditions that would make radiation unsafe Talk to your doctor to see if this trial is right for you.