RecruitingNot ApplicableNCT06879704

Radiological Prediction of Response to Neoadjuvant Chemoimmunotherapy for Triple-negative Breast Cancer

Quadrimodal Radiological Prediction (Ultrasound, Angiography/Mammography, Magnetic Rsonance Imaging, Positron Emission Tomography-computed Tomgraphy Scan) of Response to Neoadjuvant Chemoimmunotherapy for Triple-negative Breast Cancer


Sponsor

Centre Henri Becquerel

Enrollment

115 participants

Start Date

May 28, 2025

Study Type

INTERVENTIONAL

Summary

The aim of our study is to find the best imaging technique, alone or in combination, that can best predict a complete response (absence of tumour cells). It also seems important to identify blood markers able to predict which patients will benefit most from treatment, with a view to personalising them, or which patients will be most at risk of toxicities, particularly related to immunotherapy, with a view to personalising monitoring.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study uses advanced imaging (MRI and other scans) taken before and during chemotherapy plus immunotherapy to try to predict which patients with triple-negative breast cancer (TNBC) will have a complete response to treatment before surgery. The goal is to develop imaging tools that help doctors personalize treatment plans without waiting for surgery results. **You may be eligible if:** - You have a confirmed diagnosis of triple-negative breast cancer (TNBC) by biopsy - You are planning to receive neoadjuvant (pre-surgery) chemotherapy plus immunotherapy - You are between 18 and 75 years old - You are covered by or eligible for social health protection **You may NOT be eligible if:** - You are pregnant or breastfeeding - You have a contraindication to the planned treatment - You do not have confirmed TNBC - You are outside the eligible age range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERImaging assessment

The patient will have four imaging exam : Ultrasound, angio/mammography, MRI and PET-scan


Locations(1)

Centre Henri Becquerel

Rouen, France

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NCT06879704