Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis.
Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyromonas Gingivalis: A Randomized, Triple-blind Clinical Trial
Al-Mustansiriyah University
54 participants
Jan 5, 2025
INTERVENTIONAL
Conditions
Summary
The aim of the study: To assess the efficacy of antioxidant (resveratrol) mouthwash in reducing the level of p. gingivitis and oral malodor over 7 day period among undergraduate dental student patients from Mustansiriyah University/College of Dentistry and Wasit University /College of Dentistry. Objectives: * To assess the efficacy of anti-oxidant and anti-inflammatory resveratrol mouthwash in reducing halitosis in undergraduate students with plaque-induced gingivitis patients. * To assess the efficacy of resveratrol mouthwash in reducing p. gingivalis in undergraduate students' patients with oral malodor. * To determine the relation between p.gingivalis and clinical periodontal parameters (plaque index, gingival index, bleeding on probing) among undergraduate students with plaque-induced gingivitis and halitosis.
Eligibility
Inclusion Criteria8
- Organoleptic tongue of scores > 2 using (0-5scale) (Rosenberg and McCulloch, 1992)
- Male and female undergraduate dental students without chemical plaque control measures for at least one weak
- Male and female students with halitosis due to gingivitis
- The age of students ranges from 20 to 23 years.
- No periodontal treatment for at least one month
- No systemic disease
- No tobacco smoking
- The patients must have at least 20 teeth
Exclusion Criteria10
- Smokers and alcoholics
- Patient with periodontitis or pocket depth > 6mm
- Patient with orthodontics appliance
- Open carious lesions, pericoronitis, dry socket, and fistula.
- Patients with systemic disease and condition
- taking medication in the last two weeks
- Take garlic, onion, or licorice in the last 24 hours
- using oral hygiene products in the last 24 hours
- pregnant women
- sinusitis, tonsilitis, and upper respiratory tract infection
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Interventions
the participants where instruct to rinse their mouth twice daily with 10 ml of assigned mouthwash for 60 seconds for 7 days. There is currently no published research on the use of resveratrol as a mouthwash for halitosis treatment. This study aims to fill this gap by evaluating its effectiveness in reducing oral malodor through antibacterial action and the potential of volatile sulfur compounds ( VSCs)
The second group will given chlorhexidine 0.2% mouthwash as an active comparator, and will asked to rinse with 10 ml of undiluted mouthwash for 60 seconds twice per day for 7 days, and will instructed to refrain from eating and drinking for 30 min after rinsing.
the third group will given the nonactive control, distilled water, and will be asked to rinse with 10 ml of undiluted mouthwash for 60 seconds twice daily for 7 days and will be instructed to refrain from eating and drinking for 30 min after rinsing.
Locations(1)
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NCT06882564