Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners
Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners (RESPECT_1.5T Sub-study)
Mario Negri Institute for Pharmacological Research
48 participants
Apr 12, 2025
INTERVENTIONAL
Conditions
Summary
This is an interventional, multicenter, prospective study involving healthy volunteers, to primarily assess the reproducibility of multiparametric renal MRI on 1.5T scanners. The study is also aimed at assessing possible differences in renal MRI reproducibility on 1.5T MRI scanners by sex and age, and assessing possible differences in renal MRI reproducibility across field strengths (1.5T vs 3T) in the subgroup of subjects enrolled in both RESPECT clinical study and in the current subproject.
Eligibility
Inclusion Criteria5
- Provision of written informed consent prior to any study specific procedures
- Male and female subjects aged \[18-70\] years
- Office SBP values < 140 mmHg and DBP values ≤ 90 mmHg, under no antihypertensive therapy
- Normal renal function defined as: estimated glomerular filtration rate \[eGFR\] ≥ 60mL/min/1.73m2 (using CKD-EPI Creatinine Equation)
- Negative result upon urine testing for haematuria or proteinuria.
Exclusion Criteria4
- Previous enrollment in the present substudy
- Contraindications to MRI including caustrophobia, pregnancy, cardiac pacemakers or other MRI-incompatible prostheses
- Ongoing therapy (e.g. for diabetes, dyslipidemia, or any acute disease)
- Past or current oncological pathology
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Interventions
Multiparametric renal MRI on 1.5T scanners
Locations(4)
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NCT06884410