RecruitingNot ApplicableNCT06884722

Brain Mechanisms of Social Perception in Parkinson's Disease

Social Perception and Dopaminergic Modulation in Patients With Parkinson's Disease: a Functional MRI Study (Park Social-E-Motion)


Sponsor

Hospices Civils de Lyon

Enrollment

83 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Social cognition is a complex process that enables humans to interpret social information and behave appropriately in a social environment. Social cognition can be impaired in Parkinson's disease patients, worsening quality of life and relationships with those around them, even at an early stage. These alterations are manifested in particular by impairments of the recognition of facial emotions and body movements, involving the motor system. The aim of this study is to understand the brain mechanisms associated with impaired social perception in people with Parkinson's disease using functional MRI and a behavioural task for the perception of social interaction scenes depicted by "Point Light Display" (PLD).This study will investigate the effect of dopaminergic modulation on the networks associated with the perception of movement and mirror system, the observation of action (parietal cortex, superior temporal sulcus), and those associated with the mentalization of others' cognitive or emotional states (prefrontal cortex and limbic system). The study is thus divided into 2 stages. * Stage 1 "preliminary": Preliminary validation of the experimental task * Stage 2 "imagery": Assessment of brain activity (BOLD signal) related to social perception in imaging


Eligibility

Min Age: 30 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the brain processes social information — like recognizing emotions in faces or voices — in people with Parkinson's disease, compared to healthy individuals. It uses brain imaging (MRI) and behavioral tests to understand changes in social perception. **You may be eligible if...** - You are between 30 and 75 years old - You have a confirmed Parkinson's disease diagnosis for at least 3 years and are on dopaminergic medication (for patients) - You have good cognitive function (MoCA score of 26 or above) - For healthy volunteers: you have no disabling chronic disease **You may NOT be eligible if...** - You have a pacemaker or metal implants incompatible with MRI - You have claustrophobia - You have a history of significant head trauma with loss of consciousness - (Additional MRI-specific exclusions may apply) Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALBehavioral task of social perception (stage 1)

Patients with Parkinson disease and healthy volunteer are engaged in a social perception behavioral task.

OTHERFunctional magnetic resonance imaging: 3 Tesla magnetic resonance imaging (stage 2)

Patients with Parkinson disease and healthy volunteer are assessed by functional magnetic resonance imaging while they are engaged in a social perception behavioral task. 2 times for patients with Parkinson disease (during ON-levodopa and OFF-levodopa) Once for healthy volunteer

OTHERNeurological and neuropsychological assessments

Patients with Parkinson disease and healthy volunteer will undergo a neurological and neuropsychological assessment with several evaluations: weight, height, medical history, global cognitive performance (MoCA and BREF score), apathy (LARS score), depression (BDI-II score), social cognition (mini-SEA), and quality of life (PDQ39 self-questionnaire).

OTHERNeurological assessments of Parkinson's disease symptoms and caregiver burden

Patients with Parkinson disease will undergo a neurological assessment of motor and non-motor symptoms of Parkinson's disease (MDS-UPDRS III \& IV scale and MDS-NMS scale) and caregiver burden (Zarit scale).


Locations(1)

Service de neurologie - troubles du mouvement et pathologies neuromusculaires, Hôpital neurologique Pierre Wertheimer/GHE

Bron, France

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NCT06884722