RecruitingNCT06889974
Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome
Sponsor
University Hospital, Bordeaux
Enrollment
800 participants
Start Date
Jul 1, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
The TENDERS study aims to evaluate the impact of the timing of renal replacement therapy (RRT) initiation on outcomes in patients with tumor lysis syndrome (TLS) and associated acute kidney injury (AKI). The study will compare early versus delayed RRT initiation, examining the effect on renal function at 30 days post-treatment.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Adults aged ≥18 years.
- Hospitalized in the ICU between January 1, 2013, and December 31, 2023.
- Diagnosed with a hematologic malignancy or solid tumor requiring chemotherapy.
- Diagnosed with TLS based on the presence of two or more biochemical criteria (e.g., hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia) within 3 days before or 7 days after chemotherapy initiation.
Exclusion Criteria2
- Patient or family opposition to data collection for research purposes.
- Incomplete medical records that preclude data extraction.
Locations(10)
View Full Details on ClinicalTrials.gov
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NCT06889974