RecruitingNCT06889974

Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome


Sponsor

University Hospital, Bordeaux

Enrollment

800 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The TENDERS study aims to evaluate the impact of the timing of renal replacement therapy (RRT) initiation on outcomes in patients with tumor lysis syndrome (TLS) and associated acute kidney injury (AKI). The study will compare early versus delayed RRT initiation, examining the effect on renal function at 30 days post-treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a retrospective study (analyzing past medical records) looking at the best timing for starting dialysis (kidney replacement therapy) in patients who developed tumor lysis syndrome — a dangerous condition where chemotherapy breaks down cancer cells so quickly that the kidneys and blood chemistry are overwhelmed. The study covers ICU patients treated between 2013 and 2023. **You may be eligible if...** - You were a patient in an ICU between January 2013 and December 2023 (data reviewed retrospectively) - You have a blood cancer or solid tumor that required chemotherapy - You were diagnosed with tumor lysis syndrome during that admission **You may NOT be eligible if...** - You or your family objected to research use of your medical data - You did not develop tumor lysis syndrome during your ICU stay Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(10)

CHU d'Angers

Angers, France

Hôpital Pellegrin

Bordeaux, France

Hôpital la cavale blanche

Brest, France

CHU Dupuytren 1

Limoges, France

Hôtel-Dieu

Nantes, France

CHR d'Orléans

Orléans, France

CH de Pau

Pau, France

Centre Urgences-Réanimations

Rennes, France

IUCT-O Hopital Purpan

Toulouse, France

Hôpital Bretonneau

Tours, France

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NCT06889974


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