RecruitingNot ApplicableNCT06892028

EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

A Randomized Controlled Trial of Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder


Sponsor

Wave Neuroscience

Enrollment

110 participants

Start Date

Feb 12, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.


Eligibility

Min Age: 22 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized form of transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic pulses to stimulate specific areas of the brain — guided by brainwave (EEG) measurements to treat post-traumatic stress disorder (PTSD) in veterans and first responders. **You may be eligible if...** - You are 22–65 years old - You have a confirmed diagnosis of PTSD based on clinical interview - Your PTSD symptoms have been present for at least 6 months - You identify as a Veteran or First Responder (e.g., firefighter, paramedic, police) - Your PTSD symptom score is 31 or above on the standard checklist **You may NOT be eligible if...** - You have uncontrolled medical, psychological, or neurological conditions - You are pregnant or unwilling to use birth control during the trial - You have metal objects in your head (e.g., metal implants) - You have a history of seizures or have had TMS before with adverse effects Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEEEG-based personalized TMS

Transcranial Magnetic Stimulation (TMS), in which treatment is personalized based on the participant's Electroencephalogram (EEG)

DEVICESham Comparator

Sham Transcranial Magnetic Stimulation (TMS), in which treatment is personalized based on the participant's Electroencephalogram (EEG). No stimulation is provided.


Locations(2)

Wright State University

Dayton, Ohio, United States

D2 Human Performance Center

Pickerington, Ohio, United States

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NCT06892028


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