Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
Copenhagen Respiratory Research
1,600 participants
Mar 10, 2026
INTERVENTIONAL
Summary
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.
Eligibility
Inclusion Criteria2
- Age > 18 years
- Diagnosis of severe CAP for who the physician in charge decides for corticosteroid therapy for severe CAP.
Exclusion Criteria5
- Admitted >24 h
- Pregnant or breastfeeding women
- Active tuberculosis or fungal infection
- Pneumonia caused by influenza
- Intolerance to either study drug
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Interventions
ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.
ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.
Locations(14)
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NCT06892197