RecruitingPhase 4NCT06892210

Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Sponsor

Copenhagen Respiratory Research

Enrollment

2,000 participants

Start Date

Mar 10, 2026

Study Type

INTERVENTIONAL

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Summary

The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days. Participants will randomized to receive treatment with either hydrocortisone or prednisolone.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This trial compares two steroid medications — hydrocortisone and prednisolone — to see which works better for treating flare-ups of chronic obstructive pulmonary disease (COPD). **You may be eligible if...** - You are 40 years or older - You have been diagnosed with an acute COPD flare-up **You may NOT be eligible if...** - You have a condition that requires a specific corticosteroid - You are pregnant or breastfeeding - You have active tuberculosis or an invasive fungal infection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMethylprednisolone (drug)

ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.

DRUGHydrocortisone

ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.

Locations(14)

Bornholm Hospital

Rønne, Bornholm, Denmark

Amager Hospital

Copenhagen, Copenhagen City, Denmark

Bispebjerg Hospital

Copenhagen, Copenhagen City, Denmark

Frederiksberg Hospital

Frederiksberg, Copenhagen City, Denmark

Gentofte Hospital

Hellerup, Copenhagen City, Denmark

Herlev Hospital

Herlev, Copnhagen Surroundings, Denmark

Hvidovre Hospital

Hvidovre, Copnhagen Surroundings, Denmark

Nordsjællands Hospital

Hillerød, North Zealand, Denmark

Holbæk Sygehus

Holbæk, Region Sjælland, Denmark

University Hospital of Region Zealand, Køge

Køge, Region Sjælland, Denmark

Næstved Sygehus

Næstved, Region Sjælland, Denmark

Ringsted Sygehus

Ringsted, Region Sjælland, Denmark

University Hospital of Region Zealand, Roskilde

Roskilde, Region Sjælland, Denmark

Slagelse Sygehus

Slagelse, Region Sjælland, Denmark

View Full Details on ClinicalTrials.gov

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NCT06892210

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