Individualized Comprehensive Treatment for Advanced Hepatocellular Carcinoma

This study is testing a personalized combination treatment approach for people with advanced liver cancer (hepatocellular carcinoma) who have already tried and stopped responding to their first-line treatment (targeted therapy plus immunotherapy). The goal is to find better options for this difficult-to-treat stage. **You may be eligible if...** - You are 18 or older - You have been diagnosed with liver cancer (HCC) confirmed by biopsy or imaging - Your cancer cannot be treated with surgery or other local treatments - Your cancer has gotten worse despite first-line targeted immunotherapy treatment - Your expected survival is more than 3 months and your physical function is good (ECOG 0-1) **You may NOT be eligible if...** - You are pregnant or of childbearing age and not using contraception - You have not yet tried standard first-line treatments - You have serious organ problems or very poor overall health Talk to your doctor to see if this trial is right for you.