Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
Differential Impact of Pringle Occlusion vs. Portal Vein Occlusion-Induced Liver Ischaemia-Reperfusion Injury on Myocardial Injury Following Noncardiac Surgeries.
Beijing Tsinghua Chang Gung Hospital
800 participants
Jan 4, 2023
OBSERVATIONAL
Conditions
Summary
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms. A bidirectional cohort study will be conducted, enrolling patients scheduled for major hepato-biliary surgery. Clinical data, perioperative parameters, and postoperative follow-up data will be systematically collected. The incidence of MINS between patients undergoing Pringle occlusion and portal vein occlusion will be compared, and a multivariate analysis will be performed to identify independent risk factors for MINS, providing a basis for early recognition and prevention of MINS.
Eligibility
Inclusion Criteria4
- Age ≥ 65 years, or ≥ 45 years with cardiovascular risk factors (especially known cardiovascular disease).
- Undergoing elective major hepatopancreatobiliary surgery under general anesthesia.
- ASA physical status II-III.
- Provide written informed consent to participate in the study (applicable to the prospective cohort).
Exclusion Criteria5
- Emergency surgery
- Preoperative diagnosis of myocardial infarction or unstable angina
- Severe hepatic insufficiency (Child-Pugh class C)
- Concomitant severe organ dysfunction (e.g., renal failure, respiratory failure)
- Concomitant active infectious disease
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06895798