Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing
Baylor Research Institute
50 participants
May 21, 2025
INTERVENTIONAL
Conditions
Summary
This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.
Eligibility
Inclusion Criteria5
- Aged 18 or older
- Patient being evaluated for ANOCA or INOCA
- Clinical suspicion for angina
- Patient should be able to comply with the protocol.
- Provide written informed consent before study participation.
Exclusion Criteria6
- Existing coronary artery disease
- Previous percutaneous interventions within the coronaries
- Current use (within 48 hours) of long-acting nitrate therapies
- Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
- Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
- Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.
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Interventions
CRT will be performed in the left and right coronary arteries. Measurements will be obtained in each of the coronaries first without intracoronary nitrates followed by a dose of 200-500 mcg of intracoronary nitrates and repeat measurements.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06896903