RecruitingNot ApplicableNCT06898476

Silkworm Pupa Powder Improves Dementia.

A Prospective, Double-Blind, Randomized Controlled Trial Evaluating Silkworm Pupa Powder Versus Placebo in Improving Alzheimer's Disease Among Patients


Sponsor

Zhejiang Provincial Tongde Hospital

Enrollment

300 participants

Start Date

Apr 10, 2025

Study Type

INTERVENTIONAL

Summary

The purpose of this clinical trial is to determine whether silkworm pupa powder is effective in treating Alzheimer's disease. It will also investigate whether silkworm pupa powder can improve the nutritional and frailty status of patients with Dementia. The main questions it aims to answer are: * Will silkworm pupa powder improve the daily living conditions of patients with Alzheimer's disease? * Will silkworm pupa powder improve the nutritional status and frailty of Alzheimer's disease patients? Researchers will compare silkworm pupa powder with a placebo (a similar substance containing 0.5% silkworm pupa powder) to see if silkworm pupa powder can treat Alzheimer's disease. Participants will: * Take silkworm pupa powder or placebo daily for four months; * Visit the clinic for check-ups and tests every four weeks; * Record their symptoms and various physiological indicators.


Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether silkworm pupa powder — a natural food supplement — can help slow cognitive decline or improve symptoms in people with Alzheimer's disease. Some preliminary research suggests that compounds in silkworm pupae may have neuroprotective effects. This study aims to assess whether the supplement is safe and whether it improves memory, thinking, or daily functioning in people with mild to severe Alzheimer's disease. **You may be eligible if...** - You are between 50 and 90 years old - You have been diagnosed with probable Alzheimer's disease based on standard clinical criteria - Your disease severity ranges from mild to severe (MMSE score between 0 and 24) - Your Alzheimer's diagnosis has been confirmed by biomarker tests (such as blood tests or brain scans showing amyloid and tau proteins) - Any existing Alzheimer's medications have been at a stable dose for at least 12 weeks **You may NOT be eligible if...** - Your memory problems are caused by something other than Alzheimer's (such as stroke or another type of dementia) - You have severe depression or other significant psychiatric conditions - You have a serious medical condition (heart failure, severe kidney or liver disease) - You are allergic to silkworm products - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTSilkworm pupa powder

Silkworm pupa powder, 2 times a day, two packets (12\*2 g) each time, take with warm water, before meals, for three months

DIETARY_SUPPLEMENTPlacebo

Placebo, 2 sachets (12\*2 g) twice a day, with warm water, before meals, for three months


Locations(1)

Tongde Hospital of Zhejiang Province

Hangzhou, Zhejiang, China

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NCT06898476