Creation of a National Multicenter Platform for the Study of Inflammatory Myocardial Disease: Pre-MYO Cohort
Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
3,000 participants
Apr 9, 2023
OBSERVATIONAL
Conditions
Summary
The objectives of this project are: 1) to comprehensively characterize a large national cohort of patients with suspected myocarditis, their clinical phenotype, care management, blood and imaging biomarkers, epidemiological, environmental and genetic data; 2) to retrospectively validate the accuracy of the new hsa-RNA-Chr8:96 biomarker for the diagnosis of myocarditis compared to conventional diagnosis; 3) to identify acquired and inherited mutations, and their interaction with the environment, which explain the susceptibility to myocarditis, its severity and response to treatment; 4) to study the lower incidence in women and the influence of age, considering socio-health and genetic factors.
Eligibility
Inclusion Criteria12
- • Presence of at least one compatible symptom and at least one objective finding in diagnostic tests (Figure 2), according to the consensus document of the European Society of Cardiology (1):
- A. Clinical presentation:
- Acute chest pain: pericardial or pseudo-ischemic.
- Dyspnea on exertion or at rest for up to 3 months.
- Dyspnea on exertion or at rest for 3 months - 1 year.
- Unexplained palpitations / arrhythmias, sudden death recovered.
- Unexplained cardiogenic shock.
- B. Findings in complementary tests:
- ECG: new onset AV block, new onset bundle branch block, ST segment elevation/depression, T wave inversion
- Elevation of TnI/TnT
- Segmental or global contractility alterations not explained by other causes
- Positive Lake Louise criteria in cardiac MRI (13) (Annex III Figure S1) • Patients who have given their informed consent.
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Interventions
characterization of a large national cohort of patients with suspected myocarditis or inflammatory cardiomyopathy.
Locations(1)
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NCT06898762