Personalized Ultrasonic Brain Stimulation for Depression (R61)

This study is testing personalized ultrasound brain stimulation (focused ultrasound) as a treatment for moderate-to-severe depression in people who have not responded well to antidepressant medications or therapy. **You may be eligible if...** - You are between 18 and 65 years old - You have a primary diagnosis of major depressive disorder (moderate to severe) - Your current depressive episode has lasted at least 2 months - You have tried at least 2 antidepressant medications or therapies that did not work - You are willing to avoid changes to your psychiatric treatments during the study **You may NOT be eligible if...** - You have psychosis or bipolar disorder - You are currently pregnant or planning to become pregnant during the study - You have metal implants in your head or a pacemaker - You have a history of seizures - You are actively suicidal Talk to your doctor to see if this trial is right for you.