RecruitingNot ApplicableNCT06905223

A Pilot Study of Synbiotics in Adults With Depressive Symptoms

A Pilot Study on the Efficacy of a Synbiotic Formula (MQU10) in Improving Mood and Well-being in Adults With Mild to Moderate Depressive Symptoms

Sponsor

GenieBiome Limited

Enrollment

30 participants

Start Date

Apr 3, 2025

Study Type

INTERVENTIONAL

Conditions

Depressive Symptoms Mild to Moderate in Severity

Summary

This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Individuals aged 18 or above
Patient Health Questionnaire-9 (PHQ-9) score between 5 to 14
Literate and can complete the self-report questionnaires
Able to understand the consent and sign the informed consent form

Exclusion Criteria11

Current diagnosis of substance abuse or dependence;
A current or past history of bipolar disorder, manic or hypomanic episodes, schizophrenia, personality disorder, posttraumatic stress disorder (PTSD), intellectual disability, neurodegenerative disorders (e. g, Parkinson's disease) or organic mental disorder
Requiring immediate psychiatric care (e. g, imminently suicidal subjects) or have attempted suicide in the past 3 months
Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 4 weeks
History of severe organ failure, renal failure on dialysis, HIV infection
Active malignancy within 5 years
History of major surgery on the gastrointestinal tract, except cholecystectomy and appendectomy in the past 5 years
Night shift work
History of antibiotic use within 4 weeks
History of allergy to probiotics or lactose leading to a severe allergic reaction
Known pregnancy or lactating