RecruitingPhase 1Phase 2NCT06907043

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

A Phase 1/2, Open-label, Multicenter, Dose-escalation, and Dose-Optimization Study to Evaluate the Safety, Tolerability, and Activity of EIK1004 (IMP1707) as Monotherapy in Participants With Advanced Solid Tumors


Sponsor

Eikon Therapeutics

Enrollment

130 participants

Start Date

Apr 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the safety, tolerability, and preliminary efficacy of EIK1004 (IMP1707) in participants with recurrent advanced/metastatic breast cancer, ovarian cancer, metastatic castrate resistant prostate cancer (mCRPC) and pancreatic cancer with deleterious/suspected deleterious mutations of select homologous recombination repair (HRR) genes. Condition or disease Intervention/treatment Phase Advanced Solid Tumors Drug: EIK1004 (IMP1707) Phase 1/Phase 2


Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called EIK1004 (IMP1707), which targets a protein called PARP1, in people with advanced solid tumors including breast cancer, ovarian cancer, prostate cancer, and pancreatic cancer. **You may be eligible if...** - You are 18 or older with advanced breast, ovarian, fallopian tube, peritoneal, prostate, or pancreatic cancer - You have already received prior chemotherapy and/or hormone therapy appropriate for your cancer type - You are in good overall health (able to care for yourself) - Your organs (liver, kidneys, bone marrow) are functioning adequately - You have a life expectancy of at least 12 weeks **You may NOT be eligible if...** - You have not received prior required treatments for your cancer type - Your overall health or organ function is too poor Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGEIK1004-001 (IMP1707-001)

PARP1 selective inhibitor


Locations(10)

Sarah Cannon Research Institute at HealthOne

Denver, Colorado, United States

Florida Cancer Center

Lake Mary, Florida, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

MD Anderson

Houston, Texas, United States

NEXT Oncology

San Antonio, Texas, United States

NEXT Virginia

Fairfax, Virginia, United States

PASO Medical

Frankston, Victoria, Australia

Chongqing University Cancer Hospital

Chongqing, Chongqing Municipality, China

Cancer Hospital of Shandong First Medical University(Shandong Cancer Institute, Shandong Cancer Hospital)

Jinan, Shandong, China

Fudan University Shanghai Cancer Center

Shanghai, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06907043


Related Trials