RecruitingPhase 2NCT06907342

Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)

COSENSE-1: A Feasibility Study for Using a Functional Precision Medicine Platform to Select Oxaliplatin-based Versus Irinotecan-based Chemotherapy Regimens for Patients With Metastatic Colorectal Cancer

Sponsor

St. Olavs Hospital

Enrollment

148 participants

Start Date

May 23, 2025

Study Type

INTERVENTIONAL

Conditions

Metastatic Colorectal Cancer First-line Treatment Organoids Tumor, Colorectal Tumoroid Core Needle Biopsy

Summary

COSENSE-1 is an unblinded, phase II, single-armed, single center feasibility study for using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens, for male and female participants aged 18 and older, with microsatellite stable (MSS)/proficient mismatch repair (pMMR) metastatic colorectal cancer (mCRC), that is incurable or not resectable with curative intent.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized approach to selecting chemotherapy for people with metastatic colorectal cancer, using lab tests on tumor samples to predict which chemotherapy combination will work best for each individual patient. **You may be eligible if...** - You are 18 or older - You have colorectal cancer that has spread (metastatic) and cannot be surgically removed - Your cancer is a specific molecular type (pMMR/MSS adenocarcinoma) - You are in good overall health and have a tumor that can be biopsied - You are willing to use contraception if applicable **You may NOT be eligible if...** - Your cancer has a different molecular profile (not pMMR/MSS) - Your cancer can be surgically removed with curative intent - Your organ function or overall health is too poor Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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