Prevalence of Ethnic Neutropenia and Duffy Null Phenotype in Neonates
The Prevalence of Ethnic Neutropenia in Neonates
Kaplan Medical Center
1,000 participants
Oct 8, 2024
OBSERVATIONAL
Conditions
Summary
This is a prospective observational study designed to assess the prevalence of the Duffy null phenotype (associated with ethnic neutropenia) in neonates born at Kaplan Medical Center. Blood samples will be collected from umbilical cords (non-invasively) to evaluate Duffy antigen expression. Data on ethnicity, perinatal factors, and routine blood counts at 9-12 months (when available) will also be collected to correlate phenotype with absolute neutrophil count (ANC).
Eligibility
Inclusion Criteria3
- Neonates born at Kaplan Medical Center between 1.9.2024 and 31.12.2025
- Parental informed consent obtained
- Umbilical cord blood available for routine testing
Exclusion Criteria1
- None
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Interventions
Cord blood samples will be collected during routine G6PD testing. An additional 3 mL will be obtained non-invasively from the umbilical cord to determine the expression of Duffy antigens using serologic gel testing.
Locations(1)
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NCT06908616