Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications
University Hospital, Antwerp
100 participants
Sep 30, 2024
OBSERVATIONAL
Conditions
Summary
Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure/dysfunction and severe shock. Objectives 1. Primary Objective: To determine if the etiology of liver failure impacts the incidence of citrate-related complications in patients undergoing CRRT. 2. Secondary Objectives: To compare the efficacy of citrate anticoagulation in terms of renal recovery, filter lifespan, and patient survival between those with liver failure/dysfunction and severe shock.
Eligibility
Inclusion Criteria3
- Critically ill patients diagnosed with AKI requiring CRRT. Caution Protocol V1.0 24-07-2024
- Documented liver failure or significant liver dysfunction (e.g., elevated liver enzymes, bilirubin levels, or clinical diagnosis of liver failure) and clincal diagnosis of shock (NE of 0.25 μg/kg/min and or association of second vasopressor).
- Age ≥ 18 years.
Exclusion Criteria1
- NA
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06908746