Liver Failure Clinical Trials

15 recruiting

Liver Failure Trials at a Glance

38 actively recruiting trials for liver failure are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Guangzhou, Houston, and Beijing. Lead sponsors running liver failure studies include Third Affiliated Hospital, Sun Yat-Sen University, Institute of Liver and Biliary Sciences, India, and European Foundation for Study of Chronic Liver Failure.

Browse liver failure trials by phase

Treatments under study

About Liver Failure Clinical Trials

Looking for clinical trials for Liver Failure? There are currently 15 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Liver Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Liver Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting
Not Applicable

COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device

SarcopeniaUltrasonographyAcute-On-Chronic Liver Failure+1 more
University Hospital, Antwerp20 enrolled1 locationNCT06079021
Recruiting
Not Applicable

Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis

SepsisAcute-On-Chronic Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University192 enrolled1 locationNCT06562803
Recruiting
Phase 1Phase 2

Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome

Liver FailureSmall-for-Size Syndrome
Beijing Friendship Hospital12 enrolled1 locationNCT07312864
Recruiting
Phase 1

Safety and Effectiveness of Mesenchymal Stem Cells in Blood Purification for the Treatment of Liver Failure

Liver Failure
Kebo Zhong10 enrolled1 locationNCT06904755
Recruiting

A Study on Relationship Between Resected Normal Liver Parenchymal Volume(RNLV)and Post-Hepatectomy Liver Failure (PHLF)

Liver Failure
National Natural Science Foundation of China1,600 enrolled3 locationsNCT06366048
Recruiting
Phase 2

TReatment for ImmUne Mediated PathopHysiology

Hepatic EncephalopathyAcute Liver FailureFulminant Hepatic Failure
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)163 enrolled24 locationsNCT04862221
Recruiting
Phase 2

Empagliflozin in Patients With Cirrhosis and Ascites

CirrhosisLiver Failure
Yale University20 enrolled1 locationNCT05726032
Recruiting
Phase 1

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

Advanced or Metastatic Solid TumorLiver Failure
Gilead Sciences30 enrolled13 locationsNCT04617522
Recruiting
Not Applicable

Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure

Acute Liver Failure
Institute of Liver and Biliary Sciences, India40 enrolled1 locationNCT06831643
Recruiting
Not Applicable

ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF

Acute Liver Failure
Institute for Clinical and Experimental Medicine25 enrolled1 locationNCT07329036
Recruiting
Not Applicable

The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients

Acute-On-Chronic Liver FailureAcute on Chronic Hepatic Failure
Chulalongkorn University40 enrolled1 locationNCT05030571
Recruiting

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

HBV-related Liver CirrhosisHBV Related Acute-on-chronic Liver FailureHBV (Hepatitis B Virus)
Qilu Hospital of Shandong University100 enrolled1 locationNCT07275554
Recruiting

Risk Factors Affecting MSC Efficacy in ACLF Patients

Acute-On-Chronic Liver Failure
Sun Yat-sen University446 enrolled1 locationNCT07198854
Recruiting
Phase 2

F573 for Injection for the Treatment of Liver Injury/Failure

Acute-On-Chronic Liver FailureAcute Liver Failure
Beijing Continent Pharmaceutical Co, Ltd.97 enrolled10 locationsNCT05689645
Recruiting
Phase 1

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

Liver DiseasesCirrhosis, LiverLiver Failure
University of Chicago24 enrolled1 locationNCT06871111
Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Liver Transplant; ComplicationsLiver CirrhosisLiver Diseases+1 more
European Foundation for Study of Chronic Liver Failure3,000 enrolled106 locationsNCT04613921
Recruiting
Phase 3

Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas)

Kidney FailureLiver Failure, ChronicKidney-Pancreas Failure
Dr. F. Köhler Chemie GmbH362 enrolled4 locationsNCT03627013
Recruiting
Not Applicable

Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy

Acute-On-Chronic Liver Failure
Institute of Liver and Biliary Sciences, India934 enrolled1 locationNCT06831565
Recruiting
Phase 1Phase 2

CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection

Liver CancerLiver MetastasesLiver Cirrhosis+4 more
AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC90 enrolled1 locationNCT07053488
Recruiting
Phase 1

Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults

Acute-On-Chronic Liver FailureChronic Liver Failure
RenJi Hospital10 enrolled1 locationNCT05727722