CHOLE-POSSUM PRO Validation for Prediction of Mortality After Cholecystectomy for Acute Calculous Cholecystitis: Protocol for a Prospective Multicenter Observational Study

CHOLE-POSSUM PRO is a multicenter observational study for adults 18 and older who have been diagnosed with acute calculous cholecystitis (gallbladder inflammation caused by gallstones) and are undergoing emergency cholecystectomy (gallbladder removal surgery). The study is not testing a new treatment — instead, it aims to validate a scoring tool called the CHOLE-POSSUM PRO score that predicts the risk of death within 30 days after surgery. Eligible patients must meet established diagnostic criteria for acute calculous cholecystitis, be candidates for emergency surgery during their hospital admission, and provide signed informed consent. Participation involves standard clinical care plus the collection of health data needed to test the scoring tool's accuracy. This summary was prepared as patient-facing educational content using AI assistance.