Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation
ART Fertility Clinics LLC
15 participants
Apr 7, 2025
OBSERVATIONAL
Conditions
Summary
The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.
Eligibility
Inclusion Criteria6
- Age group: 25 - 35 years old
- BMI: 20 - 30
- Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml
- Regular Menstrual Cycle: 26-35 days
- In case of previous use of hormonal contraception: wash-out period of 3 month
- Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI
Exclusion Criteria5
- History of ovarian surgery
- Pathology of the ovaries
- Mental health disorders
- Use of medication influencing brain function
- Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)
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Interventions
Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval.
Locations(2)
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NCT06910293