Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

This study is testing a new radiation treatment called diffusing alpha emitters (DaRT), which involves placing tiny radioactive seeds directly into a recurrent brain tumor (glioblastoma), to see if it is safe and feasible for patients who cannot have surgery again. **You may be eligible if...** - You are between 18 and 85 years old - You have been diagnosed with grade IV glioblastoma (a highly aggressive brain cancer) that has come back after prior treatment - Your tumor recurrence is a single lesion of 3 cm or less - You are not a candidate for surgery (due to tumor location, medical condition, or personal preference) - You previously received standard radiation (50.4–60 Gy) and concurrent temozolomide chemotherapy **You may NOT be eligible if...** - Your tumor is larger than 3 cm or has multiple lesions - You are eligible for and willing to have surgery - You have not received prior standard brain radiation Talk to your doctor to see if this trial is right for you.