Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease
Multi-Site Randomized Controlled Trial of A Multidisciplinary Intervention for Adults With Chronic Graft Versus Host Disease
Massachusetts General Hospital
350 participants
Aug 13, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.
Eligibility
Inclusion Criteria3
- Adult patients (≥ 18 years) who have undergone allogeneic HCT
- Have moderate to severe cGVHD based on patient-report
- Have ability to participate in English or Spanish language group telehealth intervention.
Exclusion Criteria3
- Patients with mild cGVHD based on their self-report.
- Patients with a major untreated psychiatric or cognitive condition which the treating oncology clinicians believes interferes with the capacity to provide informed consent.
- Patients with active relapsed disease requiring therapy.
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Interventions
Therapist-delivered multidisciplinary group-based telehealth intervention comprised of 8 sessions
Receiving a standardized booklet with evidence-based information on chronic GHVD management and HST survivorship recommendations
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06910969