EBUS-TTFB vs EBUS-TBNA for Diagnosing Inadequate Lymph Node Specimens Based on MOSE

This study is comparing two biopsy techniques — standard needle biopsy (EBUS-TBNA) versus a newer tissue sampling technique (EBUS-TTFB) — for getting adequate samples from swollen lymph nodes in the chest to diagnose lung or mediastinal conditions. **You may be eligible if...** - You are 18 or older - Your chest imaging shows enlarged lymph nodes in the chest (mediastinal or hilar area) that need a biopsy for diagnosis - Standard needle biopsy has previously produced an insufficient tissue sample (less than 30 mm of visible core from three passes) **You may NOT be eligible if...** - The enlarged lymph nodes appear to be fluid-filled cysts or abscesses - You have severe blood clotting problems - You have medical conditions that prevent bronchoscopy (such as severe lung or heart disease) - You have participated in another clinical trial in the past 3 months - You are pregnant Talk to your doctor to see if this trial is right for you.