RecruitingPhase 2NCT06915142

A Phase II Clinical Study of HRS-7058 in Combination With Antitumor Drugs in Patients With Advanced Malignant Tumour

An Phase II Clinical Study on the Safety, Tolerability and Efficacy of HRS-7058 in Combination With Antitumor Drugs in Subjects With Solid Tumors


Sponsor

Shandong Suncadia Medicine Co., Ltd.

Enrollment

300 participants

Start Date

Apr 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a multicentre, open phase II clinical study of dose escalation, dose extension and efficacy extension of HRS-7058 in combination with antitumor drugs in subjects with advanced malignant tumour. To evaluate the safety, tolerability and efficacy of HRS-7058 in combination with antitumor drugs.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called HRS-7058 + BP102, a drug called HRS-7058 + Cetuximab, and others for people with advanced malignant tumour. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHRS-7058 + SHR-1316

HRS-7058 + SHR-1316

DRUGHRS-7058 + SHR-1316 + Platinum-containing doublet chemotherapy

HRS-7058 + SHR-1316 + Platinum-containing doublet chemotherapy

DRUGHRS-7058 + Cetuximab

HRS-7058 + Cetuximab

DRUGHRS-7058 + SHR-1826

HRS-7058 + SHR-1826

DRUGHRS-7058 + SHR-1826 + SHR-1316

HRS-7058 + SHR-1826 + SHR-1316

DRUGHRS-7058 + SHR-A1202

HRS-7058 + SHR-A1202

DRUGHRS-7058 + BP102

HRS-7058 + BP102

DRUGHRS-7058 + SHR-9839

HRS-7058 + SHR-9839

DRUGHRS-7058 +SHR-A2102 +SHR-1316

HRS-7058 +SHR-A2102 +SHR-1316

DRUGHRS-7058 +SHR-9839(sc)+SHR-1316

HRS-7058 +SHR-9839(sc)+SHR-1316

DRUGHRS-7058 +SHR-1316 +BP102

HRS-7058 +SHR-1316 +BP102

DRUGHRS-7058 +SHR-A2102 +BP102

HRS-7058 +SHR-A2102 +BP102

DRUGHRS-7058 +SHR-A2102 +SHR-1316 +BP102

HRS-7058 +SHR-A2102 +SHR-1316 +BP102


Locations(2)

Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, China

Tianjin Cancer Hospital

Tianjin, Tianjin Municipality, China

View Full Details on ClinicalTrials.gov

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NCT06915142


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