Renal Perfusion and the Development of AKI Following Traumatic Injury
Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study
King's College Hospital NHS Trust
20 participants
Apr 13, 2024
OBSERVATIONAL
Conditions
Summary
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Eligibility
Inclusion Criteria4
- Age \> 18 years
- Within 24 hours of ICU admission following traumatic injury
- Received any blood products during initial resuscitation
- Lactate \> 2 mmol/l at any stage prior to study enrolment
Exclusion Criteria4
- Known intolerance to Sonovue or any other ultrasound contrast agent
- Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
- Known CKD 4 or end stage renal failure
- Pregnancy
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Interventions
Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography
Sublingual incident dark field (IDF) videomicroscopy
Continuous urinary oxygen tension
Locations(1)
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NCT06917053