RecruitingNot ApplicableNCT06919692

Maternal Left Lateral Position in Fetal Growth Restriction

Impact of Maternal Left-Lateral Recumbent Positioning in Pregnancies With Fetal Growth Restriction


Sponsor

University of Colorado, Denver

Enrollment

100 participants

Start Date

Jul 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction. This study will also help us learn about the effects of left-lateral positioning on maternal metabolomics, maternal mental health, fetal cardiac function, and delivery outcomes. The main questions it aims to answer are: * Does maternal left-lateral position in a pregnancy with fetal growth restriction improve the baby's growth? * How are maternal metabolomics, delivery outcomes, maternal mental health, and fetal cardiac function impacted by maternal left-lateral position? Researchers will compare the intervention group to pregnancies with fetal growth restriction that receive standard of care (without left-lateral positioning) to see if left-lateral position improves fetal biometry in fetal growth restriction. Participants will: * Practice left-lateral position every day for 4 hours (cumulatively) with 10-mins stretching after every hour of left-lateral position, or continue to receive standard of care * Visit the clinic once after 4 weeks for a follow-up research visit, and at the time of delivery Tracking of the physical activity and adherence to left-lateral position at home in intervention group A will be done through a fitbit (smart watch) given during enrollment. A fitbit will also be given to participants in intervention group B, receiving standard of care, to monitor their physical activity trends at home.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

  • Pregnant persons between 18 - 65 years of age, with a diagnosis of fetal growth restriction, with an estimated fetal weight less than tenth percentile
  • Participants with a singleton pregnancy between 24- and 34-weeks' gestational age
  • Participants with fluency in English or Spanish language

Exclusion Criteria6

  • Patients with a known history of deep vein thrombosis, pulmonary embolism, or hypercoagulability disorder
  • Patients with a pre-pregnancy BMI greater than 40
  • Pregnancy with severe abnormality in umbilical artery Doppler flow, including absent end-diastolic flow (AEDF) and reverse end-diastolic flow (REDF)
  • Patients receiving anticoagulation therapy
  • Pregnancy with suspected chromosomal anomalies or a multifetal pregnancy
  • Patients with an active smoking status during pregnancy

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Interventions

BEHAVIORALLeft lateral recumbent positioning

Left-lateral position is the recommended position of resting in pregnancy. The participants in the intervention group will be advised to practice this position with an intermittent 10-minute stretching after every hour of resting, with no more than 4-hours of this intervention per day.


Locations(2)

UCHealth Prenatal Diagnosis and Genetics Clinic - Anschutz Medical Campus

Aurora, Colorado, United States

CU John C. Hobbins Perinatal Center

Denver, Colorado, United States

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NCT06919692


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