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RecruitingNot ApplicableNCT06922097

Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements

Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements: the Randomized RAPID Trial

Sponsor

University of Hamburg-Eppendorf

Enrollment

186 participants

Start Date

Apr 7, 2025

Study Type

INTERVENTIONAL

Conditions

Intraoperative Bradycardia

Summary

The RAPID trial is a randomized, single-center trial investigating whether giving atropine at heart rates below 60 beats per minute versus giving atropine only at heart rates below 30 beats per minute reduces the amount of norepinephrine needed to keep MAP above 65 mmHg in non-cardiac surgery patients with intraoperative bradycardia.

Eligibility

Min Age: 50 Years

Inclusion Criteria6

  • Age ≥65 years
  • American Society of Anesthesiologists physical status III or IV
  • Chronic arterial hypertension
  • Diabetes mellitus requiring medication
  • Intraabdominal surgery
  • Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)

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Interventions

DRUGGiving atropine at heart rates below 60 beats per minute

In patients assigned to the atropine therapy at heart rates below 60 beats per minute, atropine will be given at a dose of 0.5 mg when heart rate is below 60 beats per minute for one continuous minute. A second and third atropine dose of 0.5 mg will be given if heart rate remains or again drops below 60 beats per minute for one continuous minute. Patients will not be given more than 1.5 mg atropine.

DRUGGiving atropine at heart rates below 30 beats per minute

In patients assigned to atropine therapy at heart rates below 30 beats per minute, atropine will be given at a dose of 0.5 mg when heart rate is below 30 beats per minute for one continuous minute. A second and third atropine dose of 0.5 mg will be given if heart rate remains or again drops below 30 beats per minute for one continuous minute. Patients will not be given more than 1.5 mg atropine.

Locations(1)

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

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NCT06922097