RecruitingPhase 2NCT06922994

Statin Effect on Arrhythmogenic Cardiomyopathy Disease Progression (SEARCH)

Statin Effect on Arrhythmogenic Cardiomyopathy Disease Progression


Sponsor

Centro Cardiologico Monzino

Enrollment

102 participants

Start Date

Mar 31, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if Atorvastatin 80 mg is effective to avoid functional right ventricular deterioration in patients affected by Arrhythmogenic Cardiomyopathy. It will also learn about the safety of Atorvastatin 80 mg in this type of patients. The main questions it aims to answer are: 1. Does Atorvastatin 80 mg prevent worstening of the right ventricular functioning? 2. Does Atorvastatin 80 mg prevent the worsening of electric, morphological and biomarkers deterioration? 3. What medical problems do participants have when taking Atorvastatin 80 mg? Researchers will compare Atorvastatin 80 mg to a placebo (a look-alike substance that contains no drug) to see if the drug works to treat Arrhythmogenic Cardiomyopathy. Participants will: 1. Take Atorvastatin 80 mg or a placebo every day for 18 months; 2. Visit the clinic at the enrollment and after 2, 4, 9 and 18 months for checkups and tests; 3. Make a phone call for safety check after 12, 15 and 19 months since the enrollment; 4. Fill out psychological questionnaires


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Atorvastatin 80 mg/day and a drug called Placebo atorvastatin for people with arrhythmogenic cardiomyopathy. The study is currently recruiting participants at 5 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtorvastatin 80 mg/day

Atorvastatin 80mg/day will be administered for 18 months to patients affected by Arrhythmogenic Cardiomyopathy

DRUGPlacebo atorvastatin

One tablet of placebo will be administered for 18 months to patients affected by Arrhythmogenic Cardiomyopathy


Locations(5)

Fondazione I.R.C.C.S. Policlinico San Matteo

Pavia, PV, Italy

Università Politecnica delle Marche

Ancona, Italy

Centro Cardiologico Monzino IRCSS

Milan, Italy

AORN - Ospedali dei Colli

Naples, Italy

Università degli Studi di Napoli Federico II

Naples, Italy

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NCT06922994


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