PSMA PET/MRI-Guided Prostate Biopsy for PI-RADS ≤3 and Prior Negative Biopsy

This study is looking at whether a specialised imaging scan — a PSMA PET/MRI — can find prostate cancer that was missed on a previous biopsy, especially when standard MRI showed low suspicion for cancer. **You may be eligible if...** - Your PSA (prostate cancer blood test) is above 4 ng/mL - You have had at least one prior biopsy that came back negative for cancer - Your PSA or PHI score has gone up at least twice in a row - Your recent MRI showed a PI-RADS score of 3 or lower (low to moderate suspicion) - Your prostate exam was normal **You may NOT be eligible if...** - You are under 30 or over 85 years old - You have another active cancer - You have previously received cancer treatment or prostate surgery - You cannot have the PET/MRI scan (e.g., contrast allergy, claustrophobia, or metal implants) - You have a blood clotting disorder or active prostate infection Talk to your doctor to see if this trial is right for you.