RecruitingPhase 2NCT06923826

Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC)

Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC) - A Phase 2 Multi-centre Trial


Sponsor

National University Hospital, Singapore

Enrollment

32 participants

Start Date

Apr 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if the drug, sacituzumab govitecan, works to treat: 1. Salivary gland cancers that have spread to other parts of the body or come back after previous treatment, and cannot be removed by surgery 2. A type of thyroid cancer (specifically, differentiated thyroid carcinoma) that has spread to other parts of the body or come back after previous treatment, no longer responds to radioactive iodine treatment and cannot be removed by surgery The main question it aims to answer is whether sacituzumab govitecan can treat the 2 conditions mentioned above in a safe and effective manner. Participants will: * Receive sacituzumab govitecan by intravenous (IV) infusion on Day 1 and Day 8 of each treatment cycle. Each treatment cycle is 21 days (3 weeks) long. * Visit the clinic before each infusion for checkups and blood tests * Go through CT/PET/MRI scan once every 6 weeks for the first 24 weeks, then every 9 weeks thereafter. * Go through 2 tumour biopsies (if assessed by the doctor to be safe) at the start and at the end of study participation Participants will continue to receive treatment with sacituzumab govitecan until their cancer stops responding to the drug or if they decide to withdraw from the study.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is testing sacituzumab govitecan — an antibody-drug conjugate (a targeted treatment that delivers chemotherapy directly to cancer cells) — in people with advanced salivary gland cancer or thyroid cancer that cannot be surgically removed. **You may be eligible if...** - You are 21 or older - You have been diagnosed with advanced or unresectable salivary gland cancer or thyroid cancer (confirmed by biopsy) - Your cancer can be measured on imaging scans - You have previously received at least one systemic treatment (e.g., chemotherapy) for metastatic or recurrent disease, or had no available standard treatment **You may NOT be eligible if...** - Your cancer has not progressed in the last 6 months - You have not tried any prior systemic treatment when one was available - You are pregnant or breastfeeding - You have serious heart, liver, or kidney problems affecting treatment safety Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSacituzumab govitecan

Day 1 and Day 8: Sacituzumab Govitecan will be administered at the dose of 10 mg/kg via intravenous infusion.


Locations(1)

National University Cancer Institute Singapore

Singapore, Singapore

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NCT06923826


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