RecruitingPhase 2NCT06925295

Using Xe MRI to Guide Radiation Therapy for Lung Cancer

Image-Based Functionally Adapted Radiation Therapy for Lung Cancer


Sponsor

Sean Fain

Enrollment

15 participants

Start Date

Aug 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is using xenon gas MRI — a special type of breathing scan — to take detailed images of how air moves inside the lungs. The goal is to use this information to plan more precise radiation therapy for lung cancer, protecting healthy lung tissue while targeting the tumour. **You may be eligible if...** - You are between 18 and 80 years old - You have a confirmed diagnosis of lung cancer and are scheduled for stereotactic body radiation therapy (SBRT — a highly targeted form of radiation) - You are able to give informed consent and attend the required visits **You may NOT be eligible if...** - You are under 18 or are incarcerated - You have a medical device or condition that makes MRI unsafe (based on standard MRI screening questions) - You are unable to hold your breath briefly as required for the xenon gas scan Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGXenon MRI

MRI with Xenon used for contrast

DIAGNOSTIC_TESTPulmonary Function Testing

Pulmonary function testing will include spirometry, lung volumes, DLCO and oscillometry

OTHERQuality of Life Questionnaire

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30+QLQ-LC29)

OTHERMedical Research Council Dyspnea score

modified Medical Research Council Dyspnea score (mMRC Dyspnea)

OTHERSt. George's Respiratory Questionnaire

St. George's Respiratory Questionnaire (SGRQ)

DIAGNOSTIC_TESTBlood Biomarkers

blood biomarkers of inflammation and injury (e.g. Angiopoetin-2, Interleukin-6, myofibroblast activity, BPD4)


Locations(1)

University of Iowa

Iowa City, Iowa, United States

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NCT06925295