RecruitingNot ApplicableNCT06927024

Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)

A Randomized, Sham-controlled Pilot Trial of a Novel Therapeutic Strategy (taVNS) for Autonomic Nervous System (ANS) Dysfunction in Chronic Kidney Disease (CKD)


Sponsor

NYU Langone Health

Enrollment

30 participants

Start Date

Oct 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in the chronic kidney disease (CKD) stage 3-5 setting.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive earpiece (transcutaneous auricular vagus nerve stimulator, or taVNS) — which sends gentle electrical signals through the skin of the ear to stimulate the vagus nerve — can improve kidney function and reduce inflammation in patients with chronic kidney disease (CKD). **You may be eligible if...** - You are 18 or older - You have been diagnosed with CKD stage 3–5 (kidney function significantly reduced, eGFR ≤ 60) - You are currently receiving care at NYU Nephrology outpatient clinic - You are able to provide informed consent **You may NOT be eligible if...** - You have epilepsy, Parkinson's disease, or another primary nervous system disorder - You have an implanted pacemaker, defibrillator, or chronic atrial fibrillation that prevents heart rate variability monitoring - You are currently on dialysis - You have symptomatic slow heart rate (bradycardia) - You are pregnant or incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEActive taVNS

Active taVNS delivered via the TENS Device 7000.

DEVICESham taVNS

Sham taVNS delivered via the TENS Device 7000.


Locations(1)

NYU Langone Health

New York, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06927024


Related Trials