Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension

This trial tests a procedure called renal denervation — where a catheter is used to disrupt the overactive nerves around the kidney arteries — as a treatment for high blood pressure that is not controlled with medications. **You may be eligible if...** - You have been diagnosed with high blood pressure - Your blood pressure remains high despite treatment: office systolic ≥140 mmHg, diastolic ≥90 mmHg, and home systolic average ≥135 mmHg - You are able to complete a 24-hour blood pressure monitoring test **You may NOT be eligible if...** - Your kidney arteries are not suitable for the procedure - You have previously had renal denervation - Your kidney function is significantly reduced (eGFR below 45) - You have episodes of orthostatic hypotension (blood pressure dropping when you stand) - You are pregnant or planning to become pregnant - You have type 1 diabetes or poorly controlled type 2 diabetes (HbA1c over 8%) Talk to your doctor to see if this trial is right for you.