Antidepressant Response of DMT Masked With Propofol

This study is testing whether DMT (dimethyltryptamine — a naturally occurring psychedelic compound) given alongside propofol (a sedative used to mask the psychedelic experience) can reduce symptoms of moderate to severe depression. The goal is to explore DMT's antidepressant effects while removing the psychedelic experience. **You may be eligible if...** - You are 21 or older - You have moderate to severe depression (MADRS score above 20) - You are either not on antidepressants, or have been on a stable dose for at least 4 weeks - You are fluent in German - You are willing to avoid alcohol, heavy smoking, and illicit substances during the study **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder - You have a serious heart, liver, or kidney condition - You are currently pregnant or breastfeeding - You have active suicidal thoughts with a plan - You have a substance use disorder Talk to your doctor to see if this trial is right for you.