Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study
Uppsala University Hospital
65 participants
May 5, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. The study focuses on patients over 18 years old who are having planned heart surgery with a heart-lung machine (cardiopulmonary bypass). The main questions the study aims to answer are: 1. How does oxygen consumption in the early hours after surgery relate to lactate levels (a sign of low oxygen supply to the tissues)? 2. How is oxygen consumption linked to signs of poor blood flow and organ injury (such as heart, kidney, liver, brain, and gut damage)? Researchers will measure oxygen consumption after surgery using a technique called indirect calorimetry. They will also track blood flow and oxygen use during surgery and check for signs of organ injury the day after the procedure. The study will include 65 participants. People with certain health conditions, like severe anemia, high lactate levels before surgery, or needing intensive care or extra oxygen supply before surgery, will not be included. By understanding how oxygen consumption relates to blood flow and organ injury, this research may help to better manage patients after heart surgery and reduce complications.
Eligibility
Inclusion Criteria1
- Elective cardiac surgery requiring cardiopulmonary bypass
Exclusion Criteria5
- Combined, redo or annuloplasty procedures
- Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation
- Preoperative hyperlactatemia (>2mmol/L) or anaemia (Hb <90 g/dL)
- Preoperative need for supplementary oxygen or ICU care
- Consent not obtainable.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
After arrival to the ICU, prior to cessation of iv anaesthetics and extubation, indirect calorimetry will be performed by connecting a metabolic monitor to the ventilator during a minimum of 20 minutes.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06930443