RecruitingPhase 1Phase 2NCT06930690

Dexamethasone for Ureteral STent Symptoms (DUSTS)

Dexamethasone for Ureteral STent Symptoms (DUSTS): A Randomized, Double-blinded Controlled Study


Sponsor

The Methodist Hospital Research Institute

Enrollment

70 participants

Start Date

Jun 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is: 1\) Does high-dose steroid change the quality of life score on day 2 after surgery Researchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and pain Participants will: 1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery 2. fill out a questionnaire day 1 and day 2 after surgery 3. fill out a medication diary for one week after surgery 4. visit the clinic on day 2 after surgery for checkup 5. visit the clinic on day 4-7 after surgery for check up


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dexamethasone Sodium Phosphate Injection 20 mg and a drug called Dexamethasone Sodium Phosphate Injection 4mg for people with ureteral stent-related symptom. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexamethasone Sodium Phosphate Injection 20 mg

dexamethasone 20 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia

DRUGDexamethasone Sodium Phosphate Injection 4mg

dexamethasone 4 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia


Locations(1)

Houston Methodist Hospital

Houston, Texas, United States

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NCT06930690


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