RecruitingPhase 2NCT06932458

A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases

A Phase II Single-arm Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases


Sponsor

Western University, Canada

Enrollment

30 participants

Start Date

Jul 17, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Testicular cancer represents 1% of adult neoplasms and is the most common solid malignancy in young men. At diagnosis, approximately 90% of cases are germ cell tumours (GCT), categorised as either seminoma (55-60%) or non-seminoma types (40-45%). For many years, the management of patients with CS IIA/B seminoma and retroperitoneal lymph node involvement ≤ 3 cm are eligible for treatment with either radiotherapy or chemotherapy Despite high cure rates for CS II seminoma (approximately 90%) with chemotherapy or radiotherapy, concerns persist regarding short and long-term treatment-related toxicities (such as increased risks of cardiovascular disease and secondary malignancies As such, an alternative strategy which has been explored in this study is the role of RPLND for the management of these patients


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether surgery to remove lymph nodes in the back of the abdomen (retroperitoneal lymph node dissection) is a better treatment option for men with testicular seminoma — a type of testicular cancer — that has spread in a limited way to nearby lymph nodes. The goal is to see if surgery can replace radiation or chemotherapy in these early-spread cases. **You may be eligible if...** - You are an adult male with a confirmed diagnosis of testicular seminoma - Your cancer has spread to lymph nodes behind the abdomen, but only in a limited way (small metastases) - You have not yet received treatment for this spread (treatment-naive) - You are in good enough health to undergo surgery **You may NOT be eligible if...** - Your cancer has spread widely or to distant organs - You have already received chemotherapy or radiation for this cancer - You have serious other health conditions that make surgery too risky - You have a different type of testicular cancer (non-seminoma) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURERetroperitoneal Lymph Node Dissection

Open bilateral nerve-sparing RPLND.


Locations(1)

London Health Sciences Centre

London, Ontario, Canada

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NCT06932458


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