RecruitingPhase 1NCT06934044

A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple Myeloma

A Phase Ib, Open-Label, Single-Arm, Multicenter Trial Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Patients With Relapsed or Refractory Multiple Myeloma


Sponsor

Hoffmann-La Roche

Enrollment

20 participants

Start Date

May 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the pharmacokinetics (PK), safety, and efficacy of cevostamab in participants with relapsed or refractory (R/R) multiple myeloma (MM).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a drug behaves in the body (pharmacokinetics) — including how it is absorbed, distributed, and eliminated — as well as its safety and effectiveness in a specific patient population. The focus is on ensuring the right dose is given to the right patients. **You may be eligible if...** - You have the specific condition this drug is being tested for - You meet the age and health requirements of the study - You have not received treatments that would interfere with results - You are willing to provide blood samples at specified time points **You may NOT be eligible if...** - You have significant liver or kidney impairment that could affect how the drug is processed - You take medications that strongly interact with the study drug - You are pregnant or breastfeeding - You have a history of severe allergic reactions to similar drugs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCevostamab

Cevostamab will be administered intravenously on a 21-day cycle.

DRUGTocilizumab

Tocilizumab will be administered for the treatment of cytokine release syndrome (CRS) when necessary.


Locations(5)

Sun yat-sen University Cancer Center

Guangzhou, Guangdong, China

Tianjin Institute of Hematology & Blood Diseases Hospital

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

View Full Details on ClinicalTrials.gov

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NCT06934044


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