RecruitingPhase 1NCT06934447

Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE

Study of BCMA/CD70 Targeted Chimeric Antigen Receptor T (CAR- T) Therapy for Refractory Childhood-oneset Systemic Lupus Erythematosus

Sponsor

The Children's Hospital of Zhejiang University School of Medicine

Enrollment

18 participants

Start Date

Apr 25, 2025

Study Type

INTERVENTIONAL

Conditions

CAR-T Cell Therapy Systemic Lupus Erythematosus BCMA

Summary

This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-BCMA/CD70 CAR-T cells in the treatment of refractory systemic lupus erythematosus.

Eligibility

Min Age: 5 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called anti-BCMA/CD70-CAR-T cells for people with bcma, car-t cell therapy, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 5 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALanti-BCMA/CD70-CAR-T cells

Three dose groups (0.3×105/kg, 1×105/kg, 3×105/kg) were set up, starting from the low dose group climbing to explore the safe and effective dose.

Locations(1)

hildren's Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT06934447

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