Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals

Exclusion Criteria15

• Allergy or intolerance to ingredients included in the mixed meal
• History of Orthostatic Hypotension (OH) or Postural Orthostatic Tachycardia Syndrome (POTS) or other autonomic dysfunction at the discretion of the investigators
• Anaemia (haemoglobin below normal range <7.3 mmol/L for women and <8.3 mmol/L for men)
• Kidney disease (estimated glomerular filtration rate (eGFR) <90 ml/min/1.73 m2) at screening
• Known liver disease and/or elevated plasma alanine aminotransferase (ALT) > three times the upper limit of normal at screening
• Treatment with antihypertensives
• Treatment with GLP-1RA (Glucagon-like Peptide-1 Receptor Agonist)
• Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within two weeks before the first experimental day
• Any ongoing medication that the investigator evaluates would interfere with trial participation
• Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses
• Any concomitant disease or treatment that, at the discretion of the investigators, might jeopardize the participant's safety during the trial
• Alcohol/drug abuse as per discretion of the investigators
• Pregnancy or breastfeeding
• Participation in any other clinical trial during the study period
• Mental incapacity or language barriers that preclude adequate understanding or cooperation or unwillingness to comply with trial requirements or pr discretion of the investigator