RecruitingPhase 1NCT06936735

A Phase I Study of HS-20108 in Participants With Advanced Solid Tumors

A Phase I Clinical Study Evaluating Safety, Tolerability, Pharmacokinetics and Efficacy of Intravenous HS-20108 in Participants With Advanced Solid Tumors

Sponsor

Hansoh BioMedical R&D Company

Enrollment

502 participants

Start Date

May 29, 2025

Study Type

INTERVENTIONAL

Conditions

Advanced Solid Tumor

Summary

This is a Phase I clinical study of HS-20108. The purpose of this study is to evaluate the safety, tolerability, PK and efficacy of intravenous HS-20108 in patients with advanced solid tumors.

Eligibility

Min Age: 18 Years

Inclusion Criteria9

Men or women aged more than or equal to (≥) 18 years.
Participants with pathologically confirmed advanced solid tumors.
At least one measurable lesion in accordance with RECIST 1.1
Fresh or archival tumor tissue available for submission.
Eastern Cooperative Oncology Group (ECOG) performance status: 0~1.
Estimated life expectancy >12 weeks.
Reproductive-age women agree to use adequate contraception and cannot breastfeed while participating in this study and for a period of 6 months after the last dose. Likewise, men also consent to use adequate contraceptive method within the same time limit.
Females must have evidence of non-childbearing potential.
Signed and dated Informed Consent Form.

Exclusion Criteria15

Treatment with any of the following:
Having received cytotoxic chemotherapy agents, investigational drugs, Chinese medicine treatment with anti-tumor indications, or other anti-tumor therapy (including endocrine therapy, molecular targeted therapy, or biotherapy) within 14 days before the first dose of study treatment.
Having received macromolecular anti-tumor drug therapy (including immunotherapy, such as monoclonal antibody drugs and bispecific antibody drugs) within 28 days before the first dose of study treatment.
Local radiotherapy for palliation within 2 weeks of the first dose of study drug, or patients received more than 30% of the bone marrow irradiation, or large-scale radiotherapy within 4 weeks of the first dose.
Major surgery (including craniotomy, thoracotomy, or laparotomy, etc.) within 4 weeks of the first dose of study drug.
Inadequate bone marrow reserve or serious organ dysfunction.
Uncontrolled pleural effusion or ascites or pericardial effusion.
Known and untreated, or active central nervous system metastases.
Active autoimmune diseases or active infectious disease
Known to have interstitial pneumonia or immune pneumonia
History of severe allergic reaction, serious transfusion reactions or Allergy to any component of HS-20108
The subject who is unlikely to comply with study procedures, restrictions, or requirements judged by the investigator.
The subject whose safety cannot be ensured or study assessments would be interfered judged by the investigator.
Pregnant women, breastfeeding women or woman who has a child-bearing plan during the study.
History of neuropathy or mental disorders, including epilepsy and dementia.