Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females
Ankara Yildirim Beyazıt University
24 participants
Apr 1, 2025
INTERVENTIONAL
Conditions
Summary
This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.
Eligibility
Inclusion Criteria5
- Female, aged 18 to 25 years
- Recreationally active (engaging in structured resistance training 3-4 times per week for the past 6 months)
- Regular menstrual cycles (used for scheduling purposes)
- Able and willing to provide informed consent
- Agreement to maintain normal diet and training routines throughout the study
Exclusion Criteria7
- History of musculoskeletal injury affecting lower or upper limbs within the past 6 months
- Known allergy or intolerance to creatine or maltodextrin
- Use of performance-enhancing substances or supplements within the last 30 days
- Use of recovery modalities such as massage, cryotherapy, or compression garments during the study period
- Current use of anti-inflammatory medication
- Pregnancy or breastfeeding
- Inability to comply with study protocol or scheduled assessments
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Interventions
Participants will receive 5 grams of creatine monohydrate powder dissolved in water, flavored with a sugar-free agent, 30 minutes before sleep each night for 7 days.
Visually identical placebo (maltodextrin powder, 5 g/day), flavored with a sugar-free agent, dissolved in water and consumed 30 minutes before sleep for 7 consecutive days.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06937190