Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

This randomized clinical trial compares two techniques for removing large colon polyps (at least 20 mm) during colonoscopy: cold endoscopic mucosal resection (cold EMR, using a cold snare only) versus hybrid cold EMR (combining a hot injection technique with cold snaring). The study aims to determine whether the hybrid approach lowers the risk of polyp regrowth (recurrence) without increasing complications like bleeding. Adults aged 18 or older with flat or superficially raised large polyps that have not been previously attempted for removal are eligible; patients with inflammatory bowel disease, suspected cancer, or polyps with nodules too large for a cold snare are excluded. Participation involves the polyp removal procedure followed by a follow-up colonoscopy 3–6 months later to check for recurrence. This summary was prepared as patient-facing educational content using AI assistance.