RecruitingPhase 1Phase 2NCT06938880

Study of ZGGS18 in Combination With ZG005 in Patients With Advanced Solid Tumors

A Phase I/II Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of ZGGS18 in Combination With ZG005 in Patients With Advanced Solid Tumors, Including Cervical Cancer, Hepatocellular Carcinoma, Neuroendocrine Tumors, and Lung Cancer


Sponsor

Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Enrollment

60 participants

Start Date

May 20, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This trial is designed to assess the tolerability, safety, pharmacokinetic profile, and preliminary efficacy of the combination of ZGGS18 and ZG005 in patients with advanced solid tumors, including advanced cervical cancer, hepatocellular carcinoma, neuroendocrine cancer, and lung cancer.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the combination of two investigational drugs — ZGGS18 and ZG005 — in people with advanced solid tumors (cancers that form a mass in an organ or tissue) that have stopped responding to standard treatments. This is an early-phase trial primarily focused on safety and the right dosing. **You may be eligible if...** - You are between 18 and 75 years old, any gender - You have an advanced solid tumor confirmed by biopsy or pathology - Your cancer has stopped responding to standard treatment or you cannot tolerate standard treatment - You understand the study and have signed informed consent **You may NOT be eligible if...** - Your cancer has spread to the brain or spinal cord (CNS metastases) - You have had another cancer within the past 5 years - The study investigator believes you are not a suitable candidate for other reasons Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALZGGS18 for Injection

Intravenous infusion

BIOLOGICALZG005 for Injection

Intravenous infusion


Locations(1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

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NCT06938880


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